Uric acid oxidase compound preparation and preparation method thereof

The invention relates to a urate oxidase compound preparation and a preparation method thereof, and belongs to the technical field of biological medicines. The technical problem that the activity and the stability of a urate oxidase compound preparation in the prior art are not easy to maintain is s...

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Bibliographische Detailangaben
Hauptverfasser: BAI BING, JU MENGMENG, XIU YUAN, DU YAN, GUO WENYING, XU LE, XIU LAIGUI, ZONG GUIBIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a urate oxidase compound preparation and a preparation method thereof, and belongs to the technical field of biological medicines. The technical problem that the activity and the stability of a urate oxidase compound preparation in the prior art are not easy to maintain is solved. The urate oxidase compound preparation comprises the following components in parts by weight: 1-2 parts of urate oxidase, 1-3 parts of magnesium chloride, 0.5-1 part of vitamin B6, 2-4 parts of alanine, 0.5-2 parts of mannitol, 1-3 parts of L-cysteine and 20-30 parts of a sodium phosphate buffer solution. The urate oxidase compound preparation disclosed by the invention is good in enzyme activity, stability and clarity, and can be injected into a human body or an animal body through subcutaneous, intravenous or intramuscular injection to play a role. 本发明涉及一种尿酸氧化酶复合制剂及其制备方法,属于生物医药技术领域。解决了现有技术中尿酸氧化酶复合制剂的活性和稳定性不易保持的技术问题。本发明的尿酸氧化酶复合制剂,以重量份计,包括:1-2份尿酸氧化酶、1-3份氯化镁、0.5-1份维生素B6、2-4份丙氨酸、0.5-2份甘露醇、1-3份L-半胱氨酸、20-30份磷酸钠缓