Applications of tick analgesic protein and coding gene thereof in analgesia

The invention relates to the technical field of biology, and provides application of tick analgesic protein and a coding gene thereof in analgesia, and the analgesic protein is analgesic protein rHq023 of haemaphysalis qinghaiensis and has an amino acid sequence as shown in SEQ ID NO.1. The invention also provides a coding gene Hqi023 of the haemaphysalis qinghaiensis analgesic protein rHqi023. The Hqi023 gene comprises a nucleotide sequence SEQ ID NO.2 for coding the amino acid sequence as shown in SEQ ID NO.1. The invention also provides a preparation method of the haemaphysalis qinghaiensis analgesic protein The gene is expressed in escherichia coli, and nickel ion affinity chromatography resin is used for purification to obtain a target protein. Purified target protein is injected into the body of a mouse through intraperitoneal injection, the analgesic effect of the protein is evaluated through a thermal model, the result shows that the analgesic effect of the analgesic protein is close to that of morphi