Synthetic process of acetyl tetrapeptide-3

The invention relates to a synthesis process of acetyl tetrapeptide-3, which belongs to the field of biological peptide synthesis, and is characterized in that the process route is as follows: step 1, synthesizing an intermediate-1H-His-Lys (TFA)-OBn.HCl; step 2, synthesizing an intermediate (2Ac-Lys (TFA)-Gly-OH); step 3, synthesizing an intermediate, namely, 3Ac-Lys (TFA)-Gly-His-Lys (TFA)-OBn; step 4, synthesizing a final product, namely, Ac-Lys-Gly-His-Lys-NH2 (Ac-Lys-Gly-His-Lys-NH2) According to the method, the acetyl tetrapeptide-3 is synthesized by adopting minimum protection and four process steps through a liquid phase synthesis method, so that the production period is greatly shortened, and the production cost is reduced; and the purity of the acetyl tetrapeptide-3 prepared by using the process disclosed by the invention is more than 98%. 本发明涉及一种乙酰基四肽-3的合成工艺，属于生物肽合成领域，其特征在于，工艺路线如下：步骤一：合成中间体-1H-His-Lys(TFA)-OBn·HCl；步骤二：合成中间体-2Ac-Lys(TFA)-Gly-OH；步骤三：合成中间体-3Ac-Lys(TFA)-Gly-His-Lys(TFA)-OBn；步骤四：合成终产品Ac