Method for synthesizing lignin-based indole derivative

The invention discloses a synthesis method of a lignin-based indole derivative, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking a lignin beta-O-4 model compound and an N-methylpyrrole-2-vinyl ketone compound as reaction raw materials, heating and reacting in a solvent for a certain time in an air atmosphere under the action of a titanium catalyst and a 1, 10-phenanthroline ligand to finally obtain the lignin-based indole derivative. The synthetic method for preparing the indole derivative has the advantages of green and renewable raw materials, simplicity in operation, mild reaction conditions, high product selectivity and the like, and provides a new green way for preparing indole compounds. 本发明公开了一种木质素基吲哚衍生物的合成方法，属于有机合成技术领域。该方法以木质素β-O-4模型化合物和N-甲基吡咯-2-乙烯基酮类化合物为反应原料，空气气氛下，在钛催化剂和1,10菲咯啉配体作用下，在溶剂中加热反应一定时间，最终获得木质素基吲哚衍生物。本发明所述的制备吲哚衍生物的合成方法具有原料绿色可再生、操作简单、反应条件温和、产物选择性高等优点，为吲哚类化合物的制备提供了一条绿色的新途径。