Application of arecoline in preparation of medicine for treating type 2 diabetes mellitus and improving related metabolic disorder

The invention provides an application of arecoline in preparation of drugs for treating type 2 diabetes and improving related metabolic disorders. In-depth study is carried out in a mouse model induced by high-fat and high-fructose diet combined with streptozotocin, it is proved that intervention of...

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Hauptverfasser: LI WANGGAO, HU XIAOSONG, XU MENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides an application of arecoline in preparation of drugs for treating type 2 diabetes and improving related metabolic disorders. In-depth study is carried out in a mouse model induced by high-fat and high-fructose diet combined with streptozotocin, it is proved that intervention of arecoline not only significantly improves the blood glucose level and insulin sensitivity of T2D mice, but also shows an excellent curative effect in the aspect of glucose and lipid metabolism level, and slows down the progress of diseases. Besides, the arecoline also shows a remarkable protective effect on liver injury and improves immune inflammatory response by reducing the level of inflammatory factors, and a wider space is provided for comprehensive treatment. Therefore, the invention has remarkable innovativeness and practical value in the aspects of treating type 2 diabetes and improving related metabolic disorders, and provides an important scientific basis for developing a new generation of diabetes treat