Modified t cell receptors for prevention and treatment of viral infections and cancer

Modified T cell receptors, cells comprising the modified T cell receptors, nucleic acids encoding the modified T cell receptors, and methods of using the modified T cell receptors are contemplated. Disclosed herein are modified T cell receptors comprising two peptide chains. The two peptide chains may be the same or different, and each peptide chain comprises an extracellular domain comprising a variable region, a constant region, and a linker peptide, a transmembrane domain, and an intracellular domain comprising a CD28 region and a CD3 [zeta] ITAM region. Nucleic acids encoding the modified T cell receptors and vectors comprising the nucleic acids are also disclosed. In addition, methods for treating cancer and/or viral infections comprising administering a cell comprising the modified T cell receptor are disclosed. 设想了经修饰的T细胞受体、包含这些经修饰的T细胞受体的细胞、编码这些经修饰的T细胞受体的核酸和使用这些经修饰的T细胞受体的方法。本文披露了包含两条肽链的经修饰的T细胞受体。这两条肽链可以相同或不同，并且每条肽链包含含有可变区、恒定区和连接肽的细胞外结构域、跨膜结构域和含有CD28区域和CD3ζITAM区域的细胞内结构域。还披露了编码这些经修饰的T细胞受体的核酸以及包含这些核酸的载体。另