Synthetic method of aromatic aldehyde compound or deuterated aromatic aldehyde compound

The invention discloses a synthetic method of an aromatic aldehyde compound or a deuterated aromatic aldehyde compound, which comprises the following steps: mixing a compound shown as a formula I, a manganese catalyst, an alkaline substance, a nitrogen-containing ligand and a solvent, introducing CO...

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Hauptverfasser: LI YIBIAO, NIE JINLI, FENG YINGQI, XU YANGHAO, XIE SIJIE, HE ZIQING, CHEN LU, CHEN ZEBIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a synthetic method of an aromatic aldehyde compound or a deuterated aromatic aldehyde compound, which comprises the following steps: mixing a compound shown as a formula I, a manganese catalyst, an alkaline substance, a nitrogen-containing ligand and a solvent, introducing CO, and reacting under heating to obtain the aromatic aldehyde compound or the deuterated aromatic aldehyde compound, the structural formula of the aromatic aldehyde compound is as shown in formula II: # imgabs0 # ring A is an aromatic five-membered or six-membered ring, a substituent R comprises at least one of alkyl, halogen, substituted alkyl, alkoxy, carbonyl, ester group, nitro and cyano, or the substituent R and the ring A form a fused ring or a fused heterocyclic ring, and X is halogen. If the deuterated aromatic aldehyde compound needs to be prepared, a deuterium source reagent also needs to be added into the raw materials. The aromatic aldehyde compound can be prepared by using the manganese catalyst, the ca