Application of umbilical cord mesenchymal stem cell exosome in preparation of medicine for treating inflammatory diseases related to macrophage inflammation activation

The invention relates to the technical field of biological medicine, in particular to application of umbilical cord mesenchymal stem cell exosomes in preparation of drugs for treating inflammatory diseases related to macrophage abnormal inflammation activation, and the umbilical cord mesenchymal stem cell exosomes contain various active substances which can inhibit inflammation activation of macrophages. In a lipopolysaccharide stimulated macrophage classical inflammation model, a component containing the umbilical cord mesenchymal stem cell exosome is exogenously added, phosphorylation activation of inflammation signal channel key proteins STAT1 and STAT2 is remarkably inhibited, expression of inflammatory factors CXCL10, TNF alpha and TNFSF10 is remarkably reduced, and the umbilical cord mesenchymal stem cell exosome shows a remarkable anti-inflammatory effect. 本发明涉及生物医药技术领域，具体涉及一种脐带间充质干细胞外泌体在制备治疗巨噬细胞异常炎症激活相关炎症性疾病药物中的应用，脐带间充质干细胞外泌体含有多种活性物质可抑制巨噬细胞的炎症激活，在脂多糖刺激的巨噬细胞经典炎症模型中，外源性的加入含有脐带间充质干细胞外泌体的组份，显著抑制炎症信号通路关键蛋白