Application of NDUFA4L2 gene in regulation and control of pig muscle fiber type transformation
The invention discloses application of an NDUFA4L2 gene to regulation and control of pig muscle fiber type transformation and a method for regulating and controlling the pig muscle fiber type transformation. The method comprises the step of overexpression in pig skeletal muscle satellite cells or in...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses application of an NDUFA4L2 gene to regulation and control of pig muscle fiber type transformation and a method for regulating and controlling the pig muscle fiber type transformation. The method comprises the step of overexpression in pig skeletal muscle satellite cells or interference of NDUFA4L2 gene expression. Therefore, the m6A modification level of the target gene NDUFA4L2 subjected to m6A methylation modification in the pig muscle in the slow muscle of the pig is higher than that of the fast muscle, and the expression quantity of the gene is also high, which is a reason influencing the meat quality difference between the slow muscle fiber and the fast muscle fiber; the expression of the gene is interfered in porcine skeletal muscle satellite cells, the differentiation of the cells is inhibited, and a new method is provided for changing the cross sectional area of the muscle; moreover, overexpression of NDUFA4L2 enables muscle fibers to be converted into slow oxidizing muscle fib |
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