Lactobacillus rhamnosus for improving oxidative damage and assisting in relieving vagina inflammation through oral administration

The invention discloses a lactobacillus rhamnosus strain capable of improving oxidative damage to relieve vaginitis, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus has the effect of repairing oxidative damage related symptoms caused by vaginitis and further improvi...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN WEI, LIN RUMENG, MAO BINGYONG, ZHAO JIANXIN, TANG XIN, CUI SHUMAO, ZHANG QIUXIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a lactobacillus rhamnosus strain capable of improving oxidative damage to relieve vaginitis, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus has the effect of repairing oxidative damage related symptoms caused by vaginitis and further improving the intestinal health problem caused by vaginitis, specifically, the expression of cell Keap1 mRNA is reduced, and the content of cell supernatant Nrf2 is increased; the oxidative stress of the vagina of the mouse is improved; a Keap1/Nrf2 pathway is activated; the Nrf2 level of vaginal tissues is increased; the antioxidant capacity of the intestinal tract of the mouse is enhanced; the Keap1 mRNA level of the colon tissue is reduced; the pathological characterization of the vagina of the mouse is improved; the pathogenic bacterium load is reduced. Therefore, the lactobacillus rhamnosus CCFM1315 has a huge application prospect in products for improving and repairing vagina oxidative damage caused by vaginitis. 本发