Fully human anti-yersinia pestis neutralizing antibody and preparation method and application thereof

The invention discloses a fully human anti-yersinia pestis neutralizing antibody and a preparation method and application thereof, the neutralizing antibody comprises HCDR1-3 in a heavy chain variable region with an amino acid sequence as shown in SEQ ID NO: 4, and LCDR1-3 in a light chain variable...

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Bibliographische Detailangaben
Hauptverfasser:	ZHU FENGCAI, WU HAISHENG, LI CUNXIANG, HE JIAN, LI GUANGHUI, ZHENG BINYANG, ZHOU JIANFANG, ZHANG LI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a fully human anti-yersinia pestis neutralizing antibody and a preparation method and application thereof, the neutralizing antibody comprises HCDR1-3 in a heavy chain variable region with an amino acid sequence as shown in SEQ ID NO: 4, and LCDR1-3 in a light chain variable region with an amino acid sequence as shown in SEQ ID NO: 9, the monoclonal antibody has specific antigen binding property, excellent neutralizing activity and good animal protection effect, and can be conveniently, quickly and effectively applied to diagnosis and treatment of plague. 本发明公开了全人源抗鼠疫耶尔森菌中和性抗体及其制备方法和用途，所述中和性抗体包含氨基酸序列如SEQ ID NO:4所示的重链可变区中的HCDR1-3、氨基酸序列如SEQ ID NO:9所示的轻链可变区中的LCDR1-3，具有特异的抗原结合性、优异的中和活性以及良好的动物保护效果，可方便、快速和有效地应用于鼠疫的诊断和治疗中。