Preparation method of polydocanol and intermediate of polydocanol

The invention relates to a preparation method and an intermediate of polydodecanol, and the preparation method comprises the following steps: step S3, reacting a compound shown as a formula (III) with a compound shown as a formula (II) in the presence of alkali to obtain a compound shown as a formula (I-1); s4, the compound obtained in the step S3 and shown in the formula (I-1) is subjected to deprotection, and polydodecanol is obtained; wherein R1 is halogen, a p-toluenesulfonyl ester group or a methylsulfonyl ester group; r2 is methyl, ethyl, formyl, acetyl, methylsulfonyl, benzyl, carbobenzoxy, benzyl acyl, benzoyl or benzenesulfonyl. The preparation method provided by the invention has the advantages of simple operation, mild reaction conditions, stable process, high purity and the like. 本发明涉及一种聚多卡醇的制备方法及其中间体，所述制备方法包括：步骤S3：式（III）化合物在碱存在下与式（II）化合物发生反应，反应得到式（I-1）化合物；步骤S4：步骤S3得到的式（I-1）化合物经脱保护得到聚多卡醇；其中，R1为卤素、对甲苯磺酰酯基或甲磺酰酯基；R2为甲基、乙基、甲酰基、乙酰基、甲磺酰基、苄基、苄氧羰基、苄酰基、苯酰基或苯磺酰基。本发明提供的制备方法具有操作简单、反应条件温、工艺稳定以及纯度高等优势。