Heterocyclic compound with AKT kinase inhibition activity and preparation method and medical application thereof

The invention provides a heterocyclic compound with AKT kinase inhibition activity and a preparation method and medical application thereof. Specifically, the invention provides a compound shown in a general formula (I), a preparation method of the compound, a pharmaceutical composition containing t...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN ZHENHUA, CAI XUCAN, LIU GUOBIAO, SHANG FEI, YAN XU, DU PEIJIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a heterocyclic compound with AKT kinase inhibition activity and a preparation method and medical application thereof. Specifically, the invention provides a compound shown in a general formula (I), a preparation method of the compound, a pharmaceutical composition containing the compound and application of the compound serving as an AKT kinase inhibitor in drugs for preventing and/or treating abnormal cell growth such as cancer. The definition of each group in general formula (I) is the same as the definition in the description. # imgabs0 # 提供具有AKT激酶抑制活性的杂环化合物及其制备方法和医药用途。具体地，提供涉及通式(I)所示的化合物，其制备方法，含有其的药物组合物，以及其作为AKT激酶抑制剂在预防和/或治疗异常细胞生长如癌症的药物中的用途。通式(I)中的各基团的定义与说明书中的定义相同。#imgabs0#