Compounds and compositions for treatment of coronavirus related diseases

Provided herein are compounds and compositions for treating, managing, or preventing coronavirus-related diseases. In particular, provided herein are compounds that are inhibitors of the SARS-CoV-2 major protease (Mpro), pharmaceutical compositions comprising such compounds, methods for synthesizing such compounds, and methods of using such compounds and compositions to treat, manage, or prevent coronavirus-related diseases. 本文提供了用于治疗、管理或预防冠状病毒相关疾病的化合物和组合物。特别地，本文提供了作为SARS-CoV-2主要蛋白酶(Mpro)的抑制剂的化合物，包含此类化合物的药物组合物，用于合成此类化合物的方法以及使用此类化合物和组合物来治疗、管理或预防冠状病毒相关疾病的方法。