Intracellular delivery compositions

Intracellular delivery compositions

Provided is a protein conjugate comprising: a protein carrier comprising a polyethyleneimine; a payload that interacts with an intracellular target; and a joint. Also provided are pharmaceutical compositions comprising the protein conjugates as well as methods of using and producing the protein conj...

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Bibliographische Detailangaben
Hauptverfasser: FAGENBOY-OUNAY ROLAND, MANDEL ITZHAK, BEN-MOSHE TAMIR, LEKOVITZ, ALEXANDER, SHULMAN, AVIDOR, UZANGUETA RAQUEL R, HAKEEM MOHANNAD, SAPIR YUVAL, GOTFRIED, YECHIEL, SHILOVITZKY, OLEG, CHERZELSBURG, LUDWIG
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Provided is a protein conjugate comprising: a protein carrier comprising a polyethyleneimine; a payload that interacts with an intracellular target; and a joint. Also provided are pharmaceutical compositions comprising the protein conjugates as well as methods of using and producing the protein conjugates. 提供蛋白质缀合物，其包括：蛋白质运载体，包括聚乙烯亚胺；有效负载，与细胞内目标相互作用；和接头。还提供包括所述蛋白质缀合物的药物组合物以及使用和生产所述蛋白质缀合物的方法。