Method for photocatalytic synthesis of polyfluoro-substituted alkyl ether

The invention discloses a method for photocatalytic synthesis of polyfluoro-substituted alkyl ether, and belongs to the field of medical intermediates. The preparation method comprises the following steps: under the protection of argon, mixing p-toluenesulfonyl hydrazone, inorganic alkali, polyfluoro-substituted alkyl alcohol and a reaction solvent, sealing, illuminating under a 40W 390nm Kessil Lamps light source, controlling the distance between the light source and a reaction tube to be 4-8cm, controlling the temperature to be 25-35 DEG C, and stopping reaction after 4-16 hours to obtain the polyfluoro-substituted alkyl ether compound. The method has the advantages of cheap and easily available raw materials, simple operation, greenness and environmental protection, and provides a new way for synthesis of polyfluoro-substituted alkyl ether. 本发明公开了一种光催化合成多氟取代烷基醚的方法，属于医药中间体领域。在氩气保护下，将对甲基苯磺酰腙、无机碱、多氟取代烷基醇和反应溶剂混合，密封后在40W 390nm Kessil lamps光源下光照，光源距离反应管为4-8厘米，控制温度为25-35℃，4-16小时后停止反应，得到多氟取代烷基醚化合物。本发明原料廉价易得，操作简单，绿