Antibodies targeting coronavirus spike proteins

Antibodies targeting coronavirus spike proteins

Monoclonal antibodies, antigen binding fragments, and bispecific antibodies that specifically bind to coronavirus spike proteins, such as SARS-CoV-2, are disclosed. The use of these antibodies for inhibiting coronavirus infection, such as SARS-CoV-2 infection, is also disclosed. In addition, methods...

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Hauptverfasser: WANG LEI, KWONG PETER, RODREAU MARC, MASCOLA JOHN R, PEGOU, ALEXANDRE, MISASSI JAMES, LIANG YINXING, SHI WEI, LEDGERWOOD, JAMES, E, DUKE DAVID C, R.D.MASON, ZHANG YI, SCHRAMM, CHARLES, A, SULLIVAN NATHAN JOHN, HENRY ANDREW ROBERT, ZHOU TING
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Monoclonal antibodies, antigen binding fragments, and bispecific antibodies that specifically bind to coronavirus spike proteins, such as SARS-CoV-2, are disclosed. The use of these antibodies for inhibiting coronavirus infection, such as SARS-CoV-2 infection, is also disclosed. In addition, methods of detecting coronavirus, such as SARS-CoV-2, in a biological sample using the disclosed antibodies are disclosed. 公开了特异性结合冠状病毒刺突蛋白(如SARS-CoV-2)的单克隆抗体、抗原结合片段和双特异性抗体。还公开了这些抗体用于抑制冠状病毒感染(如SARS-CoV-2感染)的用途。此外，公开了使用所公开的抗体在生物样本中检测冠状病毒(如SARS-CoV-2)的方法。