Humanized design and expression verification of murine HA tag antibody

The invention discloses an anti-HA tag humanized antibody and expression verification thereof. The anti-HA tag humanized antibody comprises a heavy chain FR1, a heavy chain FR2, a heavy chain FR3, a heavy chain FR4 or a heavy chain of a variant thereof, and a light chain of a light chain FR1, a ligh...

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Hauptverfasser:	CHEN DINGRUI, HUANG DELI, ZHU-WAN YINHUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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creator	CHEN DINGRUI HUANG DELI ZHU-WAN YINHUI
description	The invention discloses an anti-HA tag humanized antibody and expression verification thereof. The anti-HA tag humanized antibody comprises a heavy chain FR1, a heavy chain FR2, a heavy chain FR3, a heavy chain FR4 or a heavy chain of a variant thereof, and a light chain of a light chain FR1, a light chain FR2, a light chain FR3, a light chain FR4 or a variant thereof, the amino acid sequence of the heavy chain FR1 comprises SEQ ID NO: 1 or consists of SEQ ID NO: 1; the heavy chain FR2 amino acid sequence comprises SEQ ID NO: 2 or consists of SEQ ID NO: 2; the amino acid sequence of the heavy chain FR3 comprises SEQ ID NO: 3 or consists of SEQ ID NO: 3; the heavy chain FR4 amino acid sequence comprises SEQ ID NO: 4 or consists of SEQ ID NO: 4; the amino acid sequence of the light chain FR1 comprises SEQ ID NO: 5 or consists of SEQ ID NO: 5; according to the present invention, the human-derived HA tag antibody structure is more similar to the human antibody through the gene recombination and optimization durin
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The anti-HA tag humanized antibody comprises a heavy chain FR1, a heavy chain FR2, a heavy chain FR3, a heavy chain FR4 or a heavy chain of a variant thereof, and a light chain of a light chain FR1, a light chain FR2, a light chain FR3, a light chain FR4 or a variant thereof, the amino acid sequence of the heavy chain FR1 comprises SEQ ID NO: 1 or consists of SEQ ID NO: 1; the heavy chain FR2 amino acid sequence comprises SEQ ID NO: 2 or consists of SEQ ID NO: 2; the amino acid sequence of the heavy chain FR3 comprises SEQ ID NO: 3 or consists of SEQ ID NO: 3; the heavy chain FR4 amino acid sequence comprises SEQ ID NO: 4 or consists of SEQ ID NO: 4; the amino acid sequence of the light chain FR1 comprises SEQ ID NO: 5 or consists of SEQ ID NO: 5; according to the present invention, the human-derived HA tag antibody structure is more similar to the human antibody through the gene recombination and optimization durin</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDzKM1NzMusSk1RSEktzkzPU0jMS1FIrSgoSi0uzszPUyhLLcpMy0xOLAFx8tMUckuLMvNSFTwcFUoS04GKSzKT8lMqeRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoaG5mZGJsYmlozExagAuYzOA</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>CHEN DINGRUI</creator><creator>HUANG DELI</creator><creator>ZHU-WAN YINHUI</creator><scope>EVB</scope></search><sort><creationdate>20240301</creationdate><title>Humanized design and expression verification of murine HA tag antibody</title><author>CHEN DINGRUI ; HUANG DELI ; ZHU-WAN YINHUI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117624349A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN DINGRUI</creatorcontrib><creatorcontrib>HUANG DELI</creatorcontrib><creatorcontrib>ZHU-WAN YINHUI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN DINGRUI</au><au>HUANG DELI</au><au>ZHU-WAN YINHUI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Humanized design and expression verification of murine HA tag antibody</title><date>2024-03-01</date><risdate>2024</risdate><abstract>The invention discloses an anti-HA tag humanized antibody and expression verification thereof. 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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
title	Humanized design and expression verification of murine HA tag antibody
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