T cell receptor (TCR) recognizing human hepatitis b virus (HBV) antigen and use thereof

The invention belongs to the field of biological medicine, and particularly relates to a T cell receptor (TCR) for recognizing human hepatitis B virus (HBV) antigen and application thereof. Specifically, the T cell antigen receptor (TCR) comprises CDR1, CDR2 and CDR3 of an alpha chain and CDR1, CDR2 and CDR3 of a beta chain, the amino acid sequences of the CDR1, the CDR2 and the CDR3 of the alpha chain are as shown in SEQ ID No. 2 to 4, SEQ ID No. 15 to 17, SEQ ID No. 23 to 25 or SEQ ID No. 31 to 33; the amino acid sequences of the CDR1, the CDR2 and the CDR3 of the beta chain are shown as SEQ ID No. 5 to 7, SEQ ID No. 18 to 20, SEQ ID No. 26 to 28 or SEQ ID No. 34 to 36 in sequence. 本发明属于生物医药领域，具体涉及识别人乙型肝炎病毒（HBV）抗原的T细胞受体（TCR）及其用途。具体地，本发明所述T细胞抗原受体（TCR）包括α链的CDR1、CDR2和CDR3以及β链的CDR1、CDR2和CDR3；所述α链的CDR1、CDR2、CDR3的氨基酸序列如SEQ ID No.2-4、SEQ ID NO.15-17、SEQ ID NO.23-25或SEQ ID NO.31-33所示；所述β链的CDR1、CDR2、CDR3的氨基酸序列依次如SEQ ID No.5-7、SEQ NO.18-20、SEQ NO.26-28或SEQ NO.34-36所示。