DDR1 affinity peptide and application thereof

The invention relates to the field of biological pharmacy, in particular to a DDR1 affinity peptide and application thereof. The DDR1 affinity peptide is selected from the following peptide a1, peptide a2 or a combination thereof: peptide a1: (D-Phe)-(D-Phe)-Trp-(D-Cha); and the peptide a2 is (D-Phe)-(D-Phe)-Trp-(D-Phe) or a truncated peptide of the (D-Phe)-Trp-(D-Phe) and an alanine scanning peptide. The DDR1 affinity peptide provided by the invention has a relatively good DDR1 inhibition effect, and in-vitro experiments prove that the DDR1 affinity peptide can promote chemotaxis and infiltration of CD8 + T cells and inhibit activation of a DDR1 downstream pathway, and is expected to be developed into drugs for treating solid tumors. 本发明涉及生物制药领域，尤其涉及一种DDR1亲和肽及其应用。所述DDR1亲和肽选自以下肽a1、肽a2或其组合：肽a1：(D-Phe)-(D-Phe)-Trp-(D-Cha)；肽a2：(D-Phe)-(D-Phe)-Trp-(D-Phe)或其截短肽、丙氨酸扫描肽。本发明提供的DDR1亲和肽具有较好的抑制DDR1的作用，体外实验证明其能够促进CD8+T细胞的趋化和浸润以及抑制DDR1下游通路的活化，有望开发为治疗实体瘤的药物。