Cytosine nucleoside derivative and preparation method thereof
The invention discloses a preparation method of a cytidine derivative as shown in a formula (VIII), which is characterized by comprising the following steps: firstly contacting a core intermediate compound (I) acyl halide with a long-chain alkanol ester compound under a weak base condition, then con...
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| creator | CAO BINWANG ZHANG DONGNA XU LIKUN WANG BAOGANG SONG YABIN ZHAO LIANGLIANG |
| description | The invention discloses a preparation method of a cytidine derivative as shown in a formula (VIII), which is characterized by comprising the following steps: firstly contacting a core intermediate compound (I) acyl halide with a long-chain alkanol ester compound under a weak base condition, then contacting with water, and then selectively hydrolyzing to obtain the compound as shown in the formula (VIII). # imgabs0 #
本发明公开一种式(VIII)所示的胞嘧啶核苷衍生物的制备方法，其特征在于，为该方法包括：使核心中间体化合物(I)酰卤化在弱碱条件下先与长链烷醇酯化合物接触，再与水接触，再选择性水解，从而获得式(VIII)所示化合物。#imgabs0# |
| format | Patent |
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本发明公开一种式(VIII)所示的胞嘧啶核苷衍生物的制备方法，其特征在于，为该方法包括：使核心中间体化合物(I)酰卤化在弱碱条件下先与长链烷醇酯化合物接触，再与水接触，再选择性水解，从而获得式(VIII)所示化合物。#imgabs0#</description><language>chi ; eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240301&DB=EPODOC&CC=CN&NR=117624239A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240301&DB=EPODOC&CC=CN&NR=117624239A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CAO BINWANG</creatorcontrib><creatorcontrib>ZHANG DONGNA</creatorcontrib><creatorcontrib>XU LIKUN</creatorcontrib><creatorcontrib>WANG BAOGANG</creatorcontrib><creatorcontrib>SONG YABIN</creatorcontrib><creatorcontrib>ZHAO LIANGLIANG</creatorcontrib><title>Cytosine nucleoside derivative and preparation method thereof</title><description>The invention discloses a preparation method of a cytidine derivative as shown in a formula (VIII), which is characterized by comprising the following steps: firstly contacting a core intermediate compound (I) acyl halide with a long-chain alkanol ester compound under a weak base condition, then contacting with water, and then selectively hydrolyzing to obtain the compound as shown in the formula (VIII). # imgabs0 #
本发明公开一种式(VIII)所示的胞嘧啶核苷衍生物的制备方法，其特征在于，为该方法包括：使核心中间体化合物(I)酰卤化在弱碱条件下先与长链烷醇酯化合物接触，再与水接触，再选择性水解，从而获得式(VIII)所示化合物。#imgabs0#</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB1rizJL87MS1XIK03OSQUyU1IVUlKLMssSSzLLUhUS81IUCopSCxKLgPz8PIXc1JKM_BSFkozUotT8NB4G1rTEnOJUXijNzaDo5hri7KGbWpAfn1pckJicmpdaEu_sZ2hobmZkYmRs6WhMjBoAcx0w3A</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>CAO BINWANG</creator><creator>ZHANG DONGNA</creator><creator>XU LIKUN</creator><creator>WANG BAOGANG</creator><creator>SONG YABIN</creator><creator>ZHAO LIANGLIANG</creator><scope>EVB</scope></search><sort><creationdate>20240301</creationdate><title>Cytosine nucleoside derivative and preparation method thereof</title><author>CAO BINWANG ; ZHANG DONGNA ; XU LIKUN ; WANG BAOGANG ; SONG YABIN ; ZHAO LIANGLIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117624239A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CAO BINWANG</creatorcontrib><creatorcontrib>ZHANG DONGNA</creatorcontrib><creatorcontrib>XU LIKUN</creatorcontrib><creatorcontrib>WANG BAOGANG</creatorcontrib><creatorcontrib>SONG YABIN</creatorcontrib><creatorcontrib>ZHAO LIANGLIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CAO BINWANG</au><au>ZHANG DONGNA</au><au>XU LIKUN</au><au>WANG BAOGANG</au><au>SONG YABIN</au><au>ZHAO LIANGLIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Cytosine nucleoside derivative and preparation method thereof</title><date>2024-03-01</date><risdate>2024</risdate><abstract>The invention discloses a preparation method of a cytidine derivative as shown in a formula (VIII), which is characterized by comprising the following steps: firstly contacting a core intermediate compound (I) acyl halide with a long-chain alkanol ester compound under a weak base condition, then contacting with water, and then selectively hydrolyzing to obtain the compound as shown in the formula (VIII). # imgabs0 #
本发明公开一种式(VIII)所示的胞嘧啶核苷衍生物的制备方法，其特征在于，为该方法包括：使核心中间体化合物(I)酰卤化在弱碱条件下先与长链烷醇酯化合物接触，再与水接触，再选择性水解，从而获得式(VIII)所示化合物。#imgabs0#</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | Cytosine nucleoside derivative and preparation method thereof |
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