Cytosine nucleoside derivative and preparation method thereof

The invention discloses a preparation method of a cytidine derivative as shown in a formula (VIII), which is characterized by comprising the following steps: firstly contacting a core intermediate compound (I) acyl halide with a long-chain alkanol ester compound under a weak base condition, then con...

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Hauptverfasser:	CAO BINWANG, ZHANG DONGNA, XU LIKUN, WANG BAOGANG, SONG YABIN, ZHAO LIANGLIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention discloses a preparation method of a cytidine derivative as shown in a formula (VIII), which is characterized by comprising the following steps: firstly contacting a core intermediate compound (I) acyl halide with a long-chain alkanol ester compound under a weak base condition, then contacting with water, and then selectively hydrolyzing to obtain the compound as shown in the formula (VIII). # imgabs0 # 本发明公开一种式(VIII)所示的胞嘧啶核苷衍生物的制备方法，其特征在于，为该方法包括：使核心中间体化合物(I)酰卤化在弱碱条件下先与长链烷醇酯化合物接触，再与水接触，再选择性水解，从而获得式(VIII)所示化合物。#imgabs0#