Chiral [oxoindole-pyrrolidine-beta-lactam] bis-spiro compound containing trifluoromethyl as well as preparation method and application of chiral [oxoindole-pyrrolidine-beta-lactam] bis-spiro compound

The invention discloses a chiral [oxoindole-pyrrolidine-beta-lactam] double-spiro compound containing trifluoromethyl in the technical field of organic synthesis. The structural formula of the chiral [oxoindole-pyrrolidine-beta-lactam] double-spiro compound is as follows: # imgabs0 #. The preparation method comprises the following steps: 1, sequentially adding a metal catalyst, a chiral ligand, alkali, isatin-derived trifluoromethyleneimine ylide and 3-methylene beta-lactam; adding an organic solvent to obtain a mixture, and stirring the mixture at the reaction temperature of 0-50 DEG C; and 2, after the reaction is finished, carrying out post-treatment and separation to obtain the chiral [oxoindole-pyrrolidine-beta-lactam] bis-spiro compound containing trifluoromethyl. The chiral [oxoindole-pyrrolidine-beta-lactam] bis-spiro compound containing trifluoromethyl prepared by the invention lays a material foundation for deep development of drug activity research based on new drug research and development. 本方案公开了