Refining method of paliperidone

The invention relates to the technical field of medicines, in particular to a refining method of paliperidone. The method comprises the following steps: dissolving a paliperidone crude product in a mixed solution of alcohol and water, heating until the solution is clear, cooling, growing crystals, aging, filtering and drying. According to the refining method of the paliperidone, the impurity 6-methoxy paliperidone similar to the chemical structure of the paliperidone can be effectively separated, the yield of the refined paliperidone is greater than 90%, the purity of the refined paliperidone reaches 99.86%, and the purity of the palmitic acid paliperidone synthesized by the prepared paliperidone reaches 99.88%. The refining method is simple, convenient to operate, stable in process, free of special equipment, green, environmentally friendly and more suitable for industrial large-scale production. 本发明涉及药物技术领域，具体涉及一种帕利哌酮的精制方法。所述方法包括将帕利哌酮粗品溶于醇和水的混合溶液中，加热至溶清，降温养晶，陈化，过滤，干燥，即可。本发明帕利哌酮的精制方法，能有效的分离帕利哌酮化学结构相近的杂质6-甲氧基