Sialic acid modified arctigenin liposome as well as preparation method and application thereof
The invention provides a sialic acid modified arctigenin liposome as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. Comprising the following steps: dissolving phospholipid, cholesterol, sialic acid modified octadecylamine and arctige...
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| creator | XIE QINGCHUN SONG WENYANG WANG JIU CHEN SONGSEN SHI JUN HUANG YONGTONG FENG MINDING HE YAOZHEN |
| description | The invention provides a sialic acid modified arctigenin liposome as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. Comprising the following steps: dissolving phospholipid, cholesterol, sialic acid modified octadecylamine and arctigenin in a solvent to obtain a mixed solution; performing rotary evaporation on the mixed solution to obtain a film; and mixing the film with water, and sequentially carrying out hydration treatment and ultrasonic treatment to obtain the sialic acid modified arctigenin liposome. The targeting arctigenin lipidosome and the non-targeting arctigenin lipidosome prepared in the invention have the particle sizes of (97.4 +/-2.1) nm and (101.1 +/-3.7) nm respectively, the encapsulation efficiency exceeds 80%, the in-vitro drug release amount is about 90%, the biological safety is good, and the requirements of anti-tumor intravenous injection preparations are basically met. The sialic acid modified arctigenin liposome can pr |
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| subjects | HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING |
| title | Sialic acid modified arctigenin liposome as well as preparation method and application thereof |
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