Sialic acid modified arctigenin liposome as well as preparation method and application thereof

The invention provides a sialic acid modified arctigenin liposome as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. Comprising the following steps: dissolving phospholipid, cholesterol, sialic acid modified octadecylamine and arctigenin in a solvent to obtain a mixed solution; performing rotary evaporation on the mixed solution to obtain a film; and mixing the film with water, and sequentially carrying out hydration treatment and ultrasonic treatment to obtain the sialic acid modified arctigenin liposome. The targeting arctigenin lipidosome and the non-targeting arctigenin lipidosome prepared in the invention have the particle sizes of (97.4 +/-2.1) nm and (101.1 +/-3.7) nm respectively, the encapsulation efficiency exceeds 80%, the in-vitro drug release amount is about 90%, the biological safety is good, and the requirements of anti-tumor intravenous injection preparations are basically met. The sialic acid modified arctigenin liposome can pr