Enhanced mycoplasma ovipneumoniae antigen protein TU-sheep pox virus recombinant multivalent vaccine and construction method thereof
The invention belongs to the field of immune engineering, and particularly discloses an enhanced type mycoplasma ovipneumoniae antigen protein TU-sheep pox virus recombinant multivalent vaccine and a construction method thereof.An antigen gene TU of mycoplasma ovipneumoniae is selected, and two non-...
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| creator | WANG YONGFEI LIU XIAOYAN DENG BOWEN ZHOU ZHENGGUO ZHAO YAOXIN ZHANG XI LI YOUWEN |
| description | The invention belongs to the field of immune engineering, and particularly discloses an enhanced type mycoplasma ovipneumoniae antigen protein TU-sheep pox virus recombinant multivalent vaccine and a construction method thereof.An antigen gene TU of mycoplasma ovipneumoniae is selected, and two non-specific immune genes HSP70 and I FN-gamma are added to enhance the immune effect of the antigen gene TU; the method comprises the following steps: respectively carrying out biological information analysis on goat pox virus fragments, selecting regions with strong antigenicity for gene synthesis, connecting the three gene fragments together, and respectively inserting the three gene fragments into unmarked goat pox virus expression vectors for expressing exogenous genes by using a homologous recombination method, a sheep pox virus vaccine strain recombinant multivalent vaccine expression vector for expressing three antigen genes of the mycoplasma ovipneumoniae is constructed, and then the recombinant sheep pox viru |
| format | Patent |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Enhanced mycoplasma ovipneumoniae antigen protein TU-sheep pox virus recombinant multivalent vaccine and construction method thereof |
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