Factor IX variants and their use in therapy

The present invention provides Factor IX variants, molecules comprising the variants, nucleic acids encoding the variants, compositions comprising or encoding nucleic acids of the variants, and their use in methods of modulating hemostasis, for example in the prevention or treatment of hemophilia B. The factor IX variants have improved biological properties relative to other factor IX variants and/or relative to wild-type factor IX. 本发明提供了因子IX变体、包含变体的分子、编码变体的核酸、包含变体或编码变体的核酸的组合物，以及它们在调节止血的方法中例如在预防或治疗B型血友病中的用途。因子IX变体相对于其他因子IX变体和/或相对于野生型因子IX具有改进的生物学特性。