Preparation method of tris (hydroxyalkyl) methylamine and intermediate

The invention discloses a preparation method of tris (hydroxyalkyl) methylamine and an intermediate, and belongs to the field of organic synthesis. The invention provides a novel intermediate, namely a compound 4, for synthesizing tris (hydroxyalkyl) methylamine, and the compound 4 is sequentially reacted with ozone and a reducing agent to obtain a novel intermediate compound 5; and then carrying out amino deprotection to obtain a target product tri (hydroxyalkyl) methylamine as shown in a formula 6. The method is simpler and more suitable for industrialization, and a series of tris (hydroxyalkyl) methylamine can be obtained only by changing the carbon chain length of the raw material. # imgabs0 # 本发明公开了一种三(羟基烷基)甲基胺的制备方法及中间体，属于有机合成领域。本发明提供了一种三(羟基烷基)甲基胺合成用的新中间体--化合物4，并利用其依次与臭氧和还原剂反应，得到新中间体化合物5；然后再氨基脱保护，得到式6所示的目标物--三(羟基烷基)甲基胺。本发明方法更简单，更适用于工业化且只要改变原料的碳链长度可以得到一系列三(羟基烷基)甲基胺。#imgabs0#