Preparation method of cefditoren pivoxil and intermediate thereof

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of cefditoren pivoxil and an intermediate thereof. According to the preparation method, (6R, 7R)-3-(Z)-2-(4-methylthiazol-5-yl)-8-oxo-7-(2-phenylacetamido)-5-sulfo-1-azabicyclo [4.2. 0] oct-2-ene-2-carboxylic acid 4-methoxy benzyl ester is taken as an initial raw material, a cefditoren mother nucleus is prepared through enzyme catalysis and 7-site deprotection, and then the cefditoren pivoxil is prepared. The method has the advantages of simple and easily available raw materials, greenness, safety, economy, environmental protection and the like, the purity of the cefditoren pivoxil prepared by the method exceeds 99%, no cefditoren pivoxil E isomer impurity is detected, and the cefditoren pivoxil E isomer impurity has more excellent drug efficacy and safety. 本发明属于药物合成技术领域，具体涉及一种头孢妥仑匹酯及其中间体的制备方法。本发明以(6R,7R)-3-(Z)-2-(4-甲基噻唑-5-基)-8-氧代-7-(2-苯基乙酰氨基)-5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸4-甲氧基苄基酯为起始原料，经过酶催化脱7位保护