Chiral N-imidazoline carbene as well as preparation method and application thereof

The invention relates to chiral N-imidazoline carbene as well as a preparation method and application thereof, and belongs to the technical field of chemical synthesis. The N-imidazoline carbene is synthesized with high yield and high purity by taking polysubstituted aniline and glyoxal as starting raw materials through five steps of coupling, addition, reduction, resolution and ring closing. According to the preparation method, the raw materials are easy to obtain, the reaction is easy to operate, post-treatment is relatively simple, the synthesis cost is effectively reduced, in addition, a system matched with a palladium catalyst has a relatively good catalytic effect on the carbonylation reaction of halide, a chiral resolution effect on racemization products is achieved, and the preparation method has a very good application prospect. 本发明涉及一种手性N-咪唑啉类卡宾及其制备方法与应用，属于化学合成技术领域。本发明以多取代苯胺和乙二醛为起始原料，经偶联、加成、还原、拆分、关环五步，高产率、高纯度地合成了N-咪唑啉类卡宾。该制备方法的原料易得，反应易操作、后处理较为简单，有效降低了合成成本，此外配合钯催化剂的体系对卤化物的羰基化反应具有较好的催化效果，对外消旋产物起到手性拆分的