Application of hnRNPK molecule as nasopharynx cancer chemotherapy sensitizer

The invention discloses an application of an hnRNPK molecule as a nasopharynx cancer chemotherapy sensitizer. The invention provides an application of a substance capable of inhibiting hnRNPK expression in preparation of a nasopharynx cancer chemotherapy sensitizer. The research finds that the hnRNP...

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Bibliographische Detailangaben
Hauptverfasser:	WANG DAJI, ZHENG CHAOPAN, YANG MING, YUAN LIN, KE CHAOYANG, ZHOU ZHOU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an application of an hnRNPK molecule as a nasopharynx cancer chemotherapy sensitizer. The invention provides an application of a substance capable of inhibiting hnRNPK expression in preparation of a nasopharynx cancer chemotherapy sensitizer. The research finds that the hnRNPK molecule can be used as a new therapeutic target for nasopharyngeal carcinoma chemotherapy resistance, the expression of hnRNPK is inhibited, the chemotherapy effect of nasopharyngeal carcinoma is remarkably enhanced, and the chemotherapy sensitization effect is achieved. The invention has important significance for treating nasopharynx cancer. 本发明公开了hnRNPK分子在作为鼻咽癌化疗增敏剂中的应用。本发明提供了能够抑制hnRNPK表达的物质在制备鼻咽癌化疗增敏剂中的应用。本发明研究发现hnRNPK分子可作为鼻咽癌化疗抵抗的新治疗靶点，抑制hnRNPK的表达显著增强鼻咽癌的化疗效果，起到化疗增敏的作用。本发明对于治疗鼻咽癌具有重要意义。