Derivatives of dihydroxyboryl phenylalanine

The present invention provides a novel compound which can have the property of specific uptake by cancer cells. In the present invention, a novel derivative of 4-dihydroxyboryl phenylalanine, a derivative of dihydroxyboryl phenylalanine having a heterocyclic skeleton, a derivative of dihydroxyboryl phenylalanine having a fused ring structure, or a pharmaceutically acceptable salt thereof is prepared. These compounds are specifically ingested by LAT1 in the evaluation of selective ingestion of LAT1 and LAT2, and thus have the property of being easily specifically ingested by cancer cells, and can be suitably used in neutron capture therapy and the like. A representative compound represented by formula (I) or a pharmaceutically acceptable salt thereof. # imgabs0 # 本发明提供一种可具有被癌细胞特异性摄取的性质的新化合物。本发明中，制备新型4－二羟硼基苯丙氨酸的衍生物、具有杂环骨架的二羟硼基苯丙氨酸的衍生物、或具有稠环结构的二羟硼基苯丙氨酸的衍生物或者它们的药学上可允许的盐。这些化合物在LAT1和LAT2选择性摄取的评价中，被LAT1特异性摄取，因此，具有容易被癌细胞特异性摄取的性质，能够适合用于中子俘获疗法等中。代表性的为下述式(I)表示的化合物或其药学上可允许的盐。#imgabs0#