Chicken rhinitis genetic engineering escherichia coli high-density fermentation medium and fermentation process thereof

The invention belongs to the technical field of microbial fermentation, and particularly relates to a chicken rhinitis genetic engineering escherichia coli high-density fermentation culture medium and a fermentation process thereof. The fermentation process comprises the processes of strain activation, strain purification, shake-flask culture, inoculation of a shake-flask culture solution into a seed tank for fermentation culture, and culture expression of the chicken rhinitis protein antigen in a fermentation tank. According to the chicken rhinitis genetic engineering escherichia coli high-density fermentation culture medium and the fermentation process, high-density, low-cost and relatively broad-spectrum fermentation can be realized. By optimizing the composition of a basic culture medium, the composition of a fed culture medium, culture conditions, induction initial OD600nm, a feeding mode and the like, the wet weight of each antigen can reach 140 g/L or above finally, the antigen activity is good, the pr