Targeted CLDN6 chimeric antigen receptor macrophage as well as preparation method and application thereof

The invention belongs to the technical field of cellular immunotherapy, and particularly relates to a targeted CLDN6 chimeric antigen receptor macrophage as well as a preparation method and application thereof. The invention provides a chimeric antigen receptor specifically targeting CLDN6, a gene and a recombinant expression vector of the chimeric antigen receptor, an engineered immune response cell modified by the chimeric antigen receptor specifically targeting CLDN6 and application of the immune response cell. The immune response cell modified by the chimeric antigen receptor of the specific targeting CLDN6 can kill tumor cells with high specificity and is good in safety, so that a new tumor treatment means with application prospects is provided. 本发明属于细胞免疫治疗技术领域，具体涉及一种靶向CLDN6嵌合抗原受体巨噬细胞及其制备方法和应用。本发明提供了特异性靶向CLDN6的嵌合抗原受体、及其基因和重组表达载体、工程化的特异性靶向CLDN6嵌合抗原受体修饰的免疫应答细胞及其应用。本发明的特异性靶向CLDN6的嵌合抗原受体修饰的免疫应答细胞高特异性杀死肿瘤细胞且安全性良好，从而提供了一种具有应用前景的肿瘤治疗的新手段。