Three-antigen target combined new crown recombinant NDV (Newcastle Disease Virus) vector as well as corresponding vaccine strain and vaccine

The invention discloses a new crown recombinant NDV (Newcastle Disease Virus) vector combined with three antigen targets as well as a corresponding vaccine strain and a vaccine. The recombinant NDV vector comprises a coding nucleotide sequence of a novel coronavirus S recombinant protein and coding nucleotide sequences of two novel coronavirus RBD recombinant proteins, the coding nucleotide sequence of the novel coronavirus S recombinant protein is inserted between the P gene and the M gene of the NDV vector; the coding nucleotide sequences of the two novel coronavirus RBD recombinant proteins are respectively inserted between the P gene and the M gene of the NDV vector and between the M gene and the F gene of the NDV vector. Compared with a vaccine formed by a double-target combined new crown recombinant NDV (Newcastle Disease Virus) vector, the vaccine provided by the invention has higher immunogenicity and wider-spectrum protection capability. 本发明公开了一种三抗原靶标结合的新冠重组NDV载体及相应的疫苗株和疫苗，所述重组NDV载体包括：一个新型冠状病毒S重组蛋白的编