Marine-derived gamma-pyrone compound Asperpyrone A as well as preparation method and application thereof

The invention belongs to the field of natural medicines, and discloses a gamma-pyrone compound which is obtained from a fungal fermentation product and has a structure as shown in a formula I or a medicinal salt thereof. According to the present invention, three blood tumor cell strains (Namalwa, NALM-6, Raji) are adopted as models, and the inhibition effect of the gamma-pyrone compound on tumor cell proliferation is determined; experimental results show that the compound has high cytotoxicity, and the gamma-pyrone compound or the pharmaceutical salt thereof has high inhibitory activity on various human hematologic tumor cells. The invention also discloses application of the gamma-pyrone compound or the pharmaceutical salt thereof in preparation of medicines for preventing and/or treating hematologic tumor diseases. # imgabs0 # 本发明属于天然药物领域，公开了从真菌发酵产物中获得的结构如式I所示的γ-吡喃酮类化合物或其药用盐。本发明以3株血液肿瘤细胞株(Namalwa,NALM-6,Raji)为模型，测定所述的γ-吡喃酮类化合物对肿瘤细胞增殖的抑制作用。实验结果表明，化合物具有较强的细胞毒性，表明γ-吡喃酮类化合物或其药用盐对多种人血液肿瘤细胞具有强抑制活性。本发明还公开了所述的γ-吡喃酮类