Preparation method of avibactam intermediate
The invention relates to the technical field of drug synthesis, discloses a preparation method of an avibactam intermediate, and solves the technical problems that purification is complicated, and a reagent is not environment-friendly or is not suitable for large-scale production in the prior art. T...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LI YINLAN CHEN YONG ZHAO YULING YANG QIMING DAI ZHIDONG ZHOU CUILIAN XIAO MAOLING GUO RUI HUANG JINYU |
| description | The invention relates to the technical field of drug synthesis, discloses a preparation method of an avibactam intermediate, and solves the technical problems that purification is complicated, and a reagent is not environment-friendly or is not suitable for large-scale production in the prior art. The yield of the process from the (2S, 5R)-5-((benzyloxy) amino) piperidine-2-carboxylic acid ethyl ester to the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide reaches 87%, the purification process of the process from the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide to the avibactam sodium salt is simple, the reaction conditions are mild, the method is environmentally friendly, and the method is suitable for industrial production. And large-scale industrial production can be realized.
本发明涉及药物合成技术领域，公开了一种阿维巴坦中间体的制备方法，解决现有技术中的纯化复杂，试剂对环境不友好或者不适合大规模生产的技术问题。本发明（2S，5R）-5-（（苄氧基）氨基）哌啶-2-羧酸乙酯到（2S，5R）-6-（苄氧基）-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺的过程收率高达87%，（2S，5R）-6-（苄氧基）-7-氧代 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN117486881A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN117486881A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN117486881A3</originalsourceid><addsrcrecordid>eNrjZNAJKEotSCxKLMnMz1PITS3JyE9RyE9TSCzLTEpMLknMVcjMK0ktyk1NyUwsSeVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaG5iYWZhYWho7GxKgBALV-Kik</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of avibactam intermediate</title><source>esp@cenet</source><creator>LI YINLAN ; CHEN YONG ; ZHAO YULING ; YANG QIMING ; DAI ZHIDONG ; ZHOU CUILIAN ; XIAO MAOLING ; GUO RUI ; HUANG JINYU</creator><creatorcontrib>LI YINLAN ; CHEN YONG ; ZHAO YULING ; YANG QIMING ; DAI ZHIDONG ; ZHOU CUILIAN ; XIAO MAOLING ; GUO RUI ; HUANG JINYU</creatorcontrib><description>The invention relates to the technical field of drug synthesis, discloses a preparation method of an avibactam intermediate, and solves the technical problems that purification is complicated, and a reagent is not environment-friendly or is not suitable for large-scale production in the prior art. The yield of the process from the (2S, 5R)-5-((benzyloxy) amino) piperidine-2-carboxylic acid ethyl ester to the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide reaches 87%, the purification process of the process from the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide to the avibactam sodium salt is simple, the reaction conditions are mild, the method is environmentally friendly, and the method is suitable for industrial production. And large-scale industrial production can be realized.
本发明涉及药物合成技术领域，公开了一种阿维巴坦中间体的制备方法，解决现有技术中的纯化复杂，试剂对环境不友好或者不适合大规模生产的技术问题。本发明（2S，5R）-5-（（苄氧基）氨基）哌啶-2-羧酸乙酯到（2S，5R）-6-（苄氧基）-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺的过程收率高达87%，（2S，5R）-6-（苄氧基）-7-氧代</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240202&DB=EPODOC&CC=CN&NR=117486881A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240202&DB=EPODOC&CC=CN&NR=117486881A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI YINLAN</creatorcontrib><creatorcontrib>CHEN YONG</creatorcontrib><creatorcontrib>ZHAO YULING</creatorcontrib><creatorcontrib>YANG QIMING</creatorcontrib><creatorcontrib>DAI ZHIDONG</creatorcontrib><creatorcontrib>ZHOU CUILIAN</creatorcontrib><creatorcontrib>XIAO MAOLING</creatorcontrib><creatorcontrib>GUO RUI</creatorcontrib><creatorcontrib>HUANG JINYU</creatorcontrib><title>Preparation method of avibactam intermediate</title><description>The invention relates to the technical field of drug synthesis, discloses a preparation method of an avibactam intermediate, and solves the technical problems that purification is complicated, and a reagent is not environment-friendly or is not suitable for large-scale production in the prior art. The yield of the process from the (2S, 5R)-5-((benzyloxy) amino) piperidine-2-carboxylic acid ethyl ester to the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide reaches 87%, the purification process of the process from the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide to the avibactam sodium salt is simple, the reaction conditions are mild, the method is environmentally friendly, and the method is suitable for industrial production. And large-scale industrial production can be realized.
本发明涉及药物合成技术领域，公开了一种阿维巴坦中间体的制备方法，解决现有技术中的纯化复杂，试剂对环境不友好或者不适合大规模生产的技术问题。本发明（2S，5R）-5-（（苄氧基）氨基）哌啶-2-羧酸乙酯到（2S，5R）-6-（苄氧基）-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺的过程收率高达87%，（2S，5R）-6-（苄氧基）-7-氧代</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAJKEotSCxKLMnMz1PITS3JyE9RyE9TSCzLTEpMLknMVcjMK0ktyk1NyUwsSeVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaG5iYWZhYWho7GxKgBALV-Kik</recordid><startdate>20240202</startdate><enddate>20240202</enddate><creator>LI YINLAN</creator><creator>CHEN YONG</creator><creator>ZHAO YULING</creator><creator>YANG QIMING</creator><creator>DAI ZHIDONG</creator><creator>ZHOU CUILIAN</creator><creator>XIAO MAOLING</creator><creator>GUO RUI</creator><creator>HUANG JINYU</creator><scope>EVB</scope></search><sort><creationdate>20240202</creationdate><title>Preparation method of avibactam intermediate</title><author>LI YINLAN ; CHEN YONG ; ZHAO YULING ; YANG QIMING ; DAI ZHIDONG ; ZHOU CUILIAN ; XIAO MAOLING ; GUO RUI ; HUANG JINYU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117486881A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LI YINLAN</creatorcontrib><creatorcontrib>CHEN YONG</creatorcontrib><creatorcontrib>ZHAO YULING</creatorcontrib><creatorcontrib>YANG QIMING</creatorcontrib><creatorcontrib>DAI ZHIDONG</creatorcontrib><creatorcontrib>ZHOU CUILIAN</creatorcontrib><creatorcontrib>XIAO MAOLING</creatorcontrib><creatorcontrib>GUO RUI</creatorcontrib><creatorcontrib>HUANG JINYU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI YINLAN</au><au>CHEN YONG</au><au>ZHAO YULING</au><au>YANG QIMING</au><au>DAI ZHIDONG</au><au>ZHOU CUILIAN</au><au>XIAO MAOLING</au><au>GUO RUI</au><au>HUANG JINYU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of avibactam intermediate</title><date>2024-02-02</date><risdate>2024</risdate><abstract>The invention relates to the technical field of drug synthesis, discloses a preparation method of an avibactam intermediate, and solves the technical problems that purification is complicated, and a reagent is not environment-friendly or is not suitable for large-scale production in the prior art. The yield of the process from the (2S, 5R)-5-((benzyloxy) amino) piperidine-2-carboxylic acid ethyl ester to the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide reaches 87%, the purification process of the process from the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide to the avibactam sodium salt is simple, the reaction conditions are mild, the method is environmentally friendly, and the method is suitable for industrial production. And large-scale industrial production can be realized.
本发明涉及药物合成技术领域，公开了一种阿维巴坦中间体的制备方法，解决现有技术中的纯化复杂，试剂对环境不友好或者不适合大规模生产的技术问题。本发明（2S，5R）-5-（（苄氧基）氨基）哌啶-2-羧酸乙酯到（2S，5R）-6-（苄氧基）-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺的过程收率高达87%，（2S，5R）-6-（苄氧基）-7-氧代</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN117486881A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Preparation method of avibactam intermediate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A27%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LI%20YINLAN&rft.date=2024-02-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN117486881A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |