Preparation method of avibactam intermediate

The invention relates to the technical field of drug synthesis, discloses a preparation method of an avibactam intermediate, and solves the technical problems that purification is complicated, and a reagent is not environment-friendly or is not suitable for large-scale production in the prior art. The yield of the process from the (2S, 5R)-5-((benzyloxy) amino) piperidine-2-carboxylic acid ethyl ester to the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide reaches 87%, the purification process of the process from the (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2. 1] octane-2-formamide to the avibactam sodium salt is simple, the reaction conditions are mild, the method is environmentally friendly, and the method is suitable for industrial production. And large-scale industrial production can be realized. 本发明涉及药物合成技术领域，公开了一种阿维巴坦中间体的制备方法，解决现有技术中的纯化复杂，试剂对环境不友好或者不适合大规模生产的技术问题。本发明（2S，5R）-5-（（苄氧基）氨基）哌啶-2-羧酸乙酯到（2S，5R）-6-（苄氧基）-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺的过程收率高达87%，（2S，5R）-6-（苄氧基）-7-氧代