Aryl-containing chloroethyl nitrosourea compound as well as preparation method and application thereof

The invention belongs to the field of medicines, and provides an aryl-containing chloroethyl nitrosourea compound. R is selected from-CH3,-CH2CH3 or # imgabs1 # Ar is selected from benzene, substituted benzene, # imgabs2 # or # imgabs3 #. The aryl-containing chloroethyl nitrosourea compound disclosed by the invention has a higher drug brain barrier penetrating capability, gives full play to the effect of aziridine ions, has excellent anti-glioma cell activity, and can be used for preparing a drug for treating the glioma cells. Meanwhile, the compound shows anti-tumor cell activity on various tumors. 本发明属于医药领域，提供了一种含芳基的氯乙基亚硝基脲类化合物。该含芳基的氯乙基亚硝基脲类化合物具有以下结构通式：#imgabs0#其中，R选自-CH3、-CH2CH3或#imgabs1#Ar选自苯、取代苯、#imgabs2#或#imgabs3#本发明的含芳基的氯乙基亚硝基脲类化合物具有更高的药物穿透脑屏障的能力，充分发挥氮杂环丙烷离子的作用，具有优异的抗胶质瘤细胞活性，同时对于多种肿瘤表现出抗肿瘤细胞活性。