Method for synthesizing lecdopamine

The present invention relates to a method for synthesizing ractopamine hydrochloride by using p-hydroxyacetophenone and raspberry ketone as raw materials. The p-hydroxyacetophenone is processed by catalytic brominating reaction to obtain omega-bromo-p-hydroxyacetophenone. The raspberry ketone is pro...

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Bibliographische Detailangaben
Hauptverfasser: AIQIAO MI, YAOZHONG JIANG, DAIMO CHEN
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a method for synthesizing ractopamine hydrochloride by using p-hydroxyacetophenone and raspberry ketone as raw materials. The p-hydroxyacetophenone is processed by catalytic brominating reaction to obtain omega-bromo-p-hydroxyacetophenone. The raspberry ketone is processed by oximation and catalytic hydrogenation to obtain 1-methyl-3-(4-hydroxyphenyl)-propylamine.The omega-bromo-p-hydroxyacetophenone and 1-methyl-3-(4-hydroxyphenyl)-propylamine are added in two-phase system formed from alkaline aqueous solution and ethyl acetate ,strenuously stirred and reacted, then the obtained reaction product is acidified by hydrochloric acid to obtain intermediate product hydrochloride of 1-(4-hydrophenyl)-2-£1-methyl-3-(4-hydrophenyl)-propyl|-ethylketone, then said intermediate product is processed by catalytic hydrogenation reduction so as to obtain the invented product ractopamine hydrochloride.