Application of astragalus polysaccharide as programmed necrosis inhibitor

The invention relates to a novel application of astragalus polysaccharide as a medicine, in particular to an application of the astragalus polysaccharide as a programmed necrosis inhibitor. The invention proves that the astragalus polysaccharide can effectively inhibit phosphorylation of a programmed necrosis marker RIPK1/RIPK3/MLKL activated by LPS/z-VAD and inhibit programmed necrosis of macrophages; skin thickening, scale increase and programmed necrosis marker protein expression at the lesion skin part of the imiquimod-induced psoriasis mouse are effectively improved; the marker gene expression of the LPS/z-VAD induced systemic inflammatory response syndrome mice such as weight loss, body temperature reduction and kidney programmed necrosis is effectively relieved, and a new scheme is provided for treatment of related diseases characterized by abnormal activation of programmed necrosis. 本发明涉及黄芪多糖的药物新用途，特别是作为程序性坏死抑制剂的药物用途。本发明证明黄芪多糖能有效抑制LPS/z-VAD激活的程序性坏死标志物RIPK1/RIPK3/MLKL磷酸化，抑制巨噬细胞程序性坏死；有效改善咪喹莫特诱导银屑病小鼠病变皮肤