Chiral reducing agent and method for synthesizing chiral nicotine

The invention discloses a chiral reducing agent and a method for synthesizing chiral nicotine. The chiral reducing agent is a compound 1 or a compound 2, or stereoisomers of the compound 1 and the compound 2. The structural formulas of the compound 1 and the compound 2 are shown as follows: # imgabs...

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Hauptverfasser: TAN PINGZHONG, TAN PING'AN, WANG LIMIN, SUN LINJIE, HU NA, KANG SHAODONG, DENG QIAN, CHEN LIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a chiral reducing agent and a method for synthesizing chiral nicotine. The chiral reducing agent is a compound 1 or a compound 2, or stereoisomers of the compound 1 and the compound 2. The structural formulas of the compound 1 and the compound 2 are shown as follows: # imgabs0 #, and a substituent group Ar is phenyl, 1-naphthyl or 2-naphthyl. The method comprises the following steps: reducing dehydrogenated nicotine by using a chiral reducing agent compound 1 or a compound 2 in the presence of a solvent, and hydrolyzing to obtain the chiral nicotine. The chiral nicotine can be prepared by reduction and hydrolysis reaction of dehydrogenated nicotine through the chiral reducing agent 1 and the chiral reducing agent 2 by utilizing the chiral reducing agent, the initial raw material is low in price, the reaction condition is mild, and the yield and the optical purity of nicotine synthesis are high. 本发明公开了一种手性还原剂及合成手性尼古丁的方法,所述手性还原剂为化合物1或化合物2,或化合物1、化合物2的立体异构体;化合物1和化合物2结构式如下所示,#imgabs0#其中,取代基