Preparation and application of biodegradable nano-enzyme based on zwitterionic polymer gel

The invention belongs to the field of new materials, and particularly discloses preparation and application of a biodegradable nano-enzyme based on zwitterionic polymer gel. The preparation method of the biodegradable nano-enzyme comprises the following steps: taking 2-methacryloyloxyethyl phosphory...

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Bibliographische Detailangaben
Hauptverfasser: LIU SHANGLIAN, WANG YANG, ZHENG ZHUANGZHUANG, TANG KAIYAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of new materials, and particularly discloses preparation and application of a biodegradable nano-enzyme based on zwitterionic polymer gel. The preparation method of the biodegradable nano-enzyme comprises the following steps: taking 2-methacryloyloxyethyl phosphorylcholine (MPC) as a main monomer, taking methacrylic acid (MAA) as a comonomer, taking N, N '-bis (acryloyl) cystamine (BAC) containing disulfide bonds or 2, 2-dimethylacryloyloxy-1-ethoxypropane (DMAEP) containing ketal bonds as a cross-linking agent, taking acetonitrile as a solvent, and reacting at the temperature of 50-80 DEG C to obtain the biodegradable nano-enzyme. The preparation method comprises the following steps: preparing P (MPC-s-s-MAA) or P (MPC-kettle-MAA) nanogel by adopting a reflux precipitation polymerization method; the P (MPC-s-s-MAA) or P (MPC-kettle-MAA) nanogel is used as a raw material, and the phosphate ester group in the nanogel is chelated by using FeCl2, so that the biodegradable nano