Method for cultivating animal model of human disease based on molecular marker

The invention discloses a method for cultivating a human disease animal model based on a molecular marker, and belongs to the technical field of animal model cultivation. The method for cultivating the human disease animal model based on the molecular marker specifically comprises the following step...

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Hauptverfasser: LIU QIAN, ZHOU JUNKANG, OUYANG LINGXUAN, ZHOU ZHIJUN, WEN YIXIN, ZHI WENLING, HE TIANQIONG, ZHANG DU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for cultivating a human disease animal model based on a molecular marker, and belongs to the technical field of animal model cultivation. The method for cultivating the human disease animal model based on the molecular marker specifically comprises the following steps: (1) constructing a high-quality genome map of a model animal chromosome level; (2) screening human disease susceptible SNP sites and genes of model animals; (3) establishing an optimization system of the model animal human disease molecular marker; and (4) screening model animal and human disease generation individuals. According to the invention, parent breeding is carried out through the molecular marker associated with the target character, so that the target character gene is gradually enriched in the offspring, and the expression of the target character is gradually improved. The breeding is not influenced by the environment, the selection result is reliable, the low heritability character can be obviously