Tapentadol artificial hapten, artificial antigen and preparation method and application thereof

The invention discloses a tapentadol artificial hapten, an artificial antigen and a preparation method and application of the tapentadol artificial hapten, (2R, 3R)-3-(3-methoxyphenyl)-N, N, 2-trimethylpentylamine is used as an initial raw material for synthesizing the artificial hapten to obtain the tapentadol artificial hapten as shown in a formula (I), and the tapentadol artificial hapten is coupled with bovine serum albumin to obtain the artificial antigen. The tapentadol artificial hapten maximally retains the characteristic structure of tapentadol, has an active group capable of being coupled with carrier protein, and can be used as an antigenic determinant; the tapentadol artificial antigen obtained by further preparation can be immunized to obtain the anti-tapentadol artificial antibody with high affinity, high sensitivity and strong specificity, the titer of immune serum obtained by immunizing a New Zealand white rabbit reaches up to 1: 80000, and the tapentadol artificial antigen can be used for rap