Anti-OX40L antibodies, anti-OX40L/anti-TNF alpha bispecific antibodies and uses thereof

The present invention relates to a novel antibody that specifically binds to OX40L and a bispecific antibody that specifically binds to OX40L and TNF [alpha], and more specifically, to an antibody or bispecific antibody that specifically binds to human OX40L to effectively inhibit binding of OX40 to...

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Hauptverfasser: PARK BUMAN, PARK JAE-EUN, JEONG SEUNG-HEE, LEE HYUN-MI, LEE JUNG-MIN, KANG HYUN-JU, KIM SOO-YOUNG, HA KYUNG-SIK, YOO, JUNG-MIN, SHIM EUN YOUNG, LEE YOON-JUNG, CHOI JONG-YEOL, CHO KYU-EUN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to a novel antibody that specifically binds to OX40L and a bispecific antibody that specifically binds to OX40L and TNF [alpha], and more specifically, to an antibody or bispecific antibody that specifically binds to human OX40L to effectively inhibit binding of OX40 to an OX40 receptor; a nucleic acid encoding the antibody; an expression vector comprising the nucleic acid; a transformant comprising the expression vector; a method for preparing the antibody; a pharmaceutical composition for treating an autoimmune disease or an inflammatory disease, comprising the antibody; a composition for diagnosing an autoimmune disease or an inflammatory disease, comprising the antibody; a method for diagnosing an autoimmune disease or an inflammatory disease by using the antibody; a method for providing information on the diagnosis of an autoimmune disease or an inflammatory disease by using the antibody; and a kit for providing the same. 本发明关于一种特异性结合OX40L的新颖抗体及特异性结合OX40L及TNFα的双特异性抗体,且具体而言关于