Synthesis method of flubendiamide and insecticide
The invention relates to the technical field of insecticides in the agrochemical industry, in particular to a synthetic method of flubendiamide and an insecticide. The synthesis method of the chlorfenapyr flubendiamide comprises the following steps: mixing 2-fluoro-3-nitrobenzoic acid ethyl ester, p...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to the technical field of insecticides in the agrochemical industry, in particular to a synthetic method of flubendiamide and an insecticide. The synthesis method of the chlorfenapyr flubendiamide comprises the following steps: mixing 2-fluoro-3-nitrobenzoic acid ethyl ester, paraformaldehyde, a Pd/C catalyst, an acidic compound and an ionic liquid, and carrying out a pressurized hydrogenation reduction methylation reaction. Then acylating and hydrolyzing the intermediate II, finally mixing the intermediate II with 2-trifluoromethyl-4-perfluoroisopropyl-6-bromaniline, and carrying out continuous condensation under the action of ultrasonic waves to obtain the chlorfenapyr fluobenzene bisamide. According to the synthesis method, a one-pot method is adopted during reductive methylation, and continuous production is carried out under the action of ultrasonic waves during condensation to obtain the chlorfenapyr bisamide active compound, so that the purposes of energy conservation, consumption |
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