Preparation method of epinastine hydrochloride tablet

The invention provides a preparation method of epinastine hydrochloride tablets, which belongs to the technical field of medicines and comprises the following steps: (1) weighing raw materials of the epinastine hydrochloride tablets, comprising the following components in parts by weight: 41-44 part...

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Bibliographische Detailangaben
Hauptverfasser: SHIM JAE-KWAN, ZHENG LINHAI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention provides a preparation method of epinastine hydrochloride tablets, which belongs to the technical field of medicines and comprises the following steps: (1) weighing raw materials of the epinastine hydrochloride tablets, comprising the following components in parts by weight: 41-44 parts of epinastine hydrochloride, 45-47 parts of beta-cyclodextrin, 8-12 parts of a compound disintegrating agent, 0.3-0.5 part of a lubricating agent, 150-200 parts of a filling agent, 3-5 parts of an adhesive, 50-60 parts of a sweetening agent, 1-3 parts of an antioxidant and 0.6-0.9 part of a surfactant, (2) mixing epinastine hydrochloride, beta-cyclodextrin and an ethanol water solution, and stirring at 60-65 DEG C for 30-40 minutes to obtain an inclusion compound; and (3) uniformly mixing the inclusion compound with other raw materials, and tabletting to obtain the epinastine hydrochloride tablet. The epinastine hydrochloride tablet can cover bitterness, the disintegration speed can be increased by adding the com