Dual-function acrylate hydrogel film for diffusion limiting film and attenuation of foreign matter reaction

Embodiments of the invention provide compositions useful in implantable devices, such as analyte sensors, and methods for making and using such compositions and devices. In a typical embodiment of the invention, the device is a glucose sensor comprising an analyte modulating layer formed from an acrylate hydrogel composition that modulates diffusion of glucose through the analyte modulating layer, and the analyte modulating layer further comprises a bioactive agent, the bioactive agent is selected for enhancing the biocompatibility of the analyte sensor when implanted in vivo. 本发明的实施方案提供了可用于诸如分析物传感器等可植入装置中的组合物以及用于制造和使用此类组合物和装置的方法。在本发明的典型实施方案中，该装置是包括分析物调节层的葡萄糖传感器，该分析物调节层由调节葡萄糖穿过该分析物调节层的扩散的丙烯酸酯水凝胶组合物形成，并且该分析物调节层还包含生物活性剂，该生物活性剂被选择用于增强分析物传感器在体内植入时的生物相容性。